水谷　哲也

Professional Career

経歴

1994年4月 : 財団法人 がん研究振興財団 リサーチレジデント
1995年6月 : 国立がんセンター研究所ウイルス部 研究員
1997年6月 : 北海道大学大学院獣医学研究科 環境獣医科学講座 助手
1999年4月 : The University of Texas Medical Branch at Galveston, Department of Microbiology and Immunology
2001年3月 : 北海道大学大学院獣医学研究科 環境獣医科学講座 助手
2002年 : 岡山大学医学部 非常勤講師 兼任
2003年8月 : 国立感染症研究所ウイルス第1部 主任研究官
2006年 - 2011年 : 鹿児島大学農学部 客員教授
2006年 - 2011年 : 岡山大学医学部 非常勤講師
2007年 - 2011年 : 岐阜大学連合獣医大学院 客員准教授
2008年 - 2011年 : 東京大学農学生命科学研究科 連携准教授
2011年11月 - 2013年3月 : 東京農工大学 農学部附属国際家畜感染症防疫研究教育センター 副センター長、疫学解明部門 教授
2013年4月 - 現在 : 東京農工大学 農学部附属国際家畜感染症防疫研究教育センター センター長、疫学解明部門 教授

Academic Degrees

学位

1994年 博士（獣医学）北海道大学

Research Interests

キーワード

応用獣医学、家畜伝染病学、魚病学、蜜蜂感染症学

Publications

論文

• Haneishi Y., Furuya Y., Hasegawa M., Takemae H., Tanioka Y., Mizutani T., Rossi M., Miyamoto J. Polyunsaturated fatty acids-rich dietary lipid prevents high fat diet-induced obesity in mice. Sci Rep. 2023. 13(1):5556

• Dong HV, Suzuki M, Takemae H, Jamsransuren D, Matsuda S, Nguyen HD, Mizutani T, Takeda Y, Ogawa H (2022) Viral RNA extraction using an automatic nucleic acid extractor with magnetic particles and genetic characterization of bovine viral diarrhea virus in Tokachi Province. Japan, in 2016-2017. J Vet Med Sci. 84 (11), 1543-1550

• Elbadawy M, Fujisaka K, Yamamoto H, Tsunedomi R, Nagano H, Ayame H, Ishihara Y, Mori T, Azakami D, Uchide T, Fukushima R, Abugomaa A, Kaneda M, Hideyuki M Yamawaki, Shinohara Y, Omatsu T, Mizutani T, Usui T, Sasaki K. Establishment of an experimental model of normal dog bladder organoid using a three-dimensional culture method. Biomedicine & Pharmacotherapy. 151:113105. 2022.

• Elbadawy M, Kato Y, Saito N, Hayashi K, Abugomaa A, Kobayashi M, Yoshida T, Shibutani M, Kaneda M, Yamawaki H, Mizutani T, Lim CK, Saijo M, Sasaki K, Usui T, Omatsu T. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-Associated Viruses, SARS-CoV-2 and Pteropine Orthoreovirus. Int J Mol Sci. 2021 Oct 5;22(19):10763

• Endo T, Nakagomi Y, Kawaguchi E, Hayakawa ESH, Vu HN, Takemae H, Shinohara Y, Yang D, Usui T, Mizutani T, Nakao Y, Furuya T. Anti-malarial activity in a Chinese herbal supplement containing Inonotus obliquus and Panax notoginseng. Parasitol Int. 2022 Dec 18;87:102532. doi: 10.1016/j.parint.2021.102532. Epub ahead of print. PMID: 34933121.

• Zhang W, Kataoka M, Doan YH, Oi T, Furuya T, Oba M, Mizutani T, Oka T, Li TC, Nagai M. Isolation and characterization of mammalian orthoreovirus type 3 from a fecal sample from a wild boar in Japan. Arch Virol. 2021 Jun;166(6):1671-1680.

   

• Wen R, Ochiai H, Uchiyama J, Osawa N, Oba M, Katayama Y, Li K, Omatsu T, Tamukai K, Suzuki K, Madarame H, Makino S, Mizutani T. African pygmy hedgehog adenovirus: Virus replication, virus-induced cytopathogenesis and activation of mitogen-activated protein kinase signaling pathways in infected MDCK cells. Res Vet Sci. 2021 Oct;139:152-158.

• Yashina LN, Abramov SA, Zhigalin AV, Smetannikova NA, Dupal TA, Krivopalov AV, Kikuchi F, Senoo K, Arai S, Mizutani T, Suzuki M, Cook JA, Yanagihara R. Geographic Distribution and Phylogeny of Soricine Shrew-Borne Seewis Virus and Altai Virus in Russia. Viruses. 2021 Jul 1;13(7):1286.

• Kikuchi F, Senoo K, Arai S, Tsuchiya K, Sơn NT, Motokawa M, Ranorosoa MC, Bawm S, Lin KS, Suzuki H, Unno A, Nakata K, Harada M, Tanaka-Taya K, Morikawa S, Suzuki M, Mizutani T, Yanagihara R. Rodent-Borne Orthohantaviruses in Vietnam, Madagascar and Japan. Viruses. 2021 Jul 12;13(7):1343.

• Elbadawy M, Kato Y, Saito N, Hayashi K, Abugomaa A, Kobayashi M, Yoshida T, Shibutani M, Kaneda M, Yamawaki H, Mizutani T, Lim C-K, Saijo M, Sasaki K, Usui T, Omatsu T. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-associated Viruses, SARS-CoV-2 and Pteropine orthoreovirus. International Journal of Molecular Sciences, 22 (19) 10763, 2021
• Tanaka S, Harrison RL, Arai H, Katayama Y, Mizutani T, Inoue MN, Miles J, Marshall SDG, Kitalong C, Nakai M (2021) Confirmation of Oryctes rhinoceros nudivirus infections in G-haplotype coconut rhinoceros beetles (Oryctes rhinoceros) from Palauan PCR-positive populations. Scientific Reports 11 (1), 18820. https://doi.org/10.1038/s41598-021-97426-w
• Junro Hayasaka, Yuka Nunomura, Miki Omura, Yukie Katayama, Tomoko Yokota, Nanako Osawa, Shinji Makino, Tetsuya Mizutani, Tsuyoshi Uchide, Yoshiteru Murata. Immunomodulatory effects of Lactobacillus biogenic administration in dogs. Japanese Journal of Veterinary Research, 69 (3) 175-182, 2021
• Iida A, Takemae H, Tarigan R, Kobayashi R, Kato H, Shimoda H, Omatsu T, Supratikno, Basri C, Mayasari NLPI, Agungpriyono S, Maeda K, Mizutani T, Hondo E. Viral-derived DNA invasion and individual variation in an Indonesian population of large flying fox Pteropus vampyrus. J Vet Med Sci. 2021 Jul 2;83(7):1068-1074.
• Yossapol M, Yamamoto M, Sugiyama M, Odoi JO, Omatsu T, Mizutani T, Ohya K, Asai T. Association between the bla(CTX-M-14)-harboring Escherichia coli Isolated from Weasels and Domestic Animals Reared on a University Campus. Antibiotics (Basel). 2021 Apr 13;10(4):432.
• Ando S, Matsuzawa Y, Tsurui H, Mizutani T, Hall D, Kuroda Y.　 Stochastic modelling of the effects of human-mobility restriction and viral infection characteristics on the spread of COVID-19. Sci Rep. 2021 Mar 25;11(1):6856. doi: 10.1038/s41598-021-86027-2
• Sumiya Borjigin, Nanako Osawa, Kaixin Li, Yukie Katayama, Yoshio Kawamura, Makoto Haritani, Shinji Makino, Tetsuya Mizutani, Mami Oba. Novel herpesvirus discovered in Walrus liver. Virus Genes.　DOI: 10.1007/s11262-021-01825-0, 2021
• Supriyono, Kuwata R, Torii S, Shimoda H, Ishijima K, Yonemitsu K, Minami S, Kuroda Y, Tatemoto K, Tran NTB, Takano A, Omatsu T, Mizutani T, Itokawa K, Isawa H, Sawabe K, Takasaki T, Yuliani DM, Abiyoga D, Hadi UK, Setiyono A, Hondo E, Agungpriyono S, Maeda K. Mosquito-borne viruses, insect-specific flaviviruses (family Flaviviridae, genus Flavivirus), Banna virus (family Reoviridae, genus Seadornavirus), Bogor virus (unassigned member of family Permutotetraviridae), and alphamesoniviruses 2 and 3 (family Mesoniviridae, genus Alphamesonivirus) isolated from Indonesian mosquitoes. J Vet Med Sci. 2020 Jul 31;82(7):1030-1041. doi: 10.1292/jvms.20-0261. Epub 2020 May 25
• Kikuchi F, Aoki K, Ohdachi SD, Tsuchiya K, Motokawa M, Jogahara T, Sơn NT, Bawm S, Lin KS, Thwe TL, Gamage CD, Ranorosoa MC, Omar H, Maryanto I, Suzuki H, Tanaka-Taya K, Morikawa S, Mizutani T, Suzuki M, Yanagihara R, Arai S. Genetic Diversity and Phylogeography of Thottapalayam thottimvirus (Hantaviridae) in Asian House Shrew (Suncus murinus) in Eurasia. Front Cell Infect Microbiol. 2020 Aug 27;10:438. doi: 10.3389/fcimb.2020.00438. eCollection 2020
• Sutummaporn K, Suzuki K, Machida N, Mizutani T, Park ES, Morikawa S, Furuya T. Increased proportion of apoptotic cells in cat kidney tissues infected with feline morbillivirus. Arch Virol. 2020 Nov;165(11):2647-2651. doi: 10.1007/s00705-020-04782-5. Epub 2020 Aug 26.
• Yasuoka J, Yi S, Okawa S, Tuot S, Murayama M, Huot C, Chhoun P, Yem S, Yuzuriha K, Mizutani T, Kikuchi K. Nutritional status and dietary diversity of school-age children living with HIV: a cross-sectional study in Phnom Penh, Cambodia. BMC Public Health. 2020 Jul 29;20(1):1181. doi: 10.1186/s12889-020-09238-8
• Tran GTH, Sultan S, Osman N, Hassan MI, VAN Dong H, Dao TD, Omatsu T, Katayama Y, Mizutani T, Takeda Y, Ogawa H, Imai K. Molecular characterization of full genome sequences of Newcastle disease viruses circulating among vaccinated chickens in Egypt during 2011-2013. J Vet Med Sci. 2020 Jun 24;82(6):809-816. doi: 10.1292/jvms.19-0623. Epub 2020 Apr 20
• Adenyo C, Ohya K, Qiu Y, Takashima Y, Ogawa H, Matsumoto T, Thu MJ, Sato K, Kawabata H, Katayama Y, Omatsu T, Mizutani T, Fukushi H, Katakura K, Nonaka N, Inoue-Murayama M, Boniface K, Nakao R.　 Bacterial and protozoan pathogens/symbionts in ticks infecting wild grasscutters Thryonomys swinderianus in Ghana.　Acta Trop. 2020 Feb 5:105388 doi: 10.1016/j.actatropica.2020.105388
• Sunaga F, Tsuchiaka S, Kishimoto M, Aoki H, Kakinoki M, Kure K, Okumura H, Okumura M, Okumura A, Nagai M, Omatsu T, Mizutani T.　 Development of a one-run real-time PCR detection system for pathogens associated with porcine respiratory diseases.　J Vet Med Sci. 82:2:217-223, doi: 10.1292/jvms.19-0063,2020
• Elbadawy, M., Yamanaka, M., Goto, Y., Hayashi, K., Tsunedomi, R., Hazama, S., Nagano, H., Yoshida, T., Shibutani, M., Ichikawa, R., Nakahara, J., Omatsu, T., Mizutani, T., Katayama, Y., Shinohara, Y., Abugomaa, A., Kaneda, M., Yamawaki, H., Usui, T., Sasaki, K.: Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model. Biomaterials 237:119823, 2020
• Kiyonori Kawasaki, Kenji Ohya, Tsutomu Omatsu, Yukie Katayama, Yasuhiro Takashima, Tsuyoshi Kinoshita, Justice Opare Odoi, Kotaro Sawai, Hideto Fukushi, Hirohito Ogawa, Miho Inoue-Murayama, Tetsuya Mizutani, Christopher Adenyo, Yoshiki Matsumoto, Boniface Kayang, Comparative Analysis of Fecal Microbiota in Grasscutter (Thryonomys swinderianus) and Other Herbivorous Livestock in Ghana Microorganisms 2020, 8(2), 265, https://doi.org/10.3390/microorganisms8020265
• Sakaguchi S, Nakagawa S, Mitsuhashi S, Ogawa M, Sugiyama K, Tamukai K, Koide R, Katayama Y, Nakano T, Makino S, Imanishi T, Miyazawa T, Mizutani T.　 Molecular characterization of feline paramyxovirus in Japanese cat populations.　Arch Virol. 2020 Feb,165(2):413-418　 doi: 10.1007/s00705-019-04480-x. Epub 2019 Dec 10
• Doysabas KCC, Oba M, Furuta M, Iida K, Omatsu T, Furuya T, Okada T, Sutummaporn K, Shimoda H, Wong ML, Wu CH, Ohmori Y, Kobayashi R, Hengjan Y, Yonemitsu K, Kuwata R, Kim YK, Han SH, Sohn JH, Han SH, Suzuki K, Kimura J, Maeda K, Oh HS, Endoh D, Mizutani T, Hondo E. Encephalomyocarditis virus is potentially derived from eastern bent-wing bats living in East Asian countries. Virus Res. 2019 Jan 2,259:62-67
• Huong, GTT ; Van, HD ; Duy, TD ; Iskender, S; Mairambek, I ; Omatsu, T; Katayama, Y; Mizutani, T ; Ozeki, Y ; Takeda, Y; Ogawa, H ; Imai, K Molecular characterization of a virulent strain of Newcastle disease virus isolated from a diseased chicken in Kyrgyzstan in 2016 JAPANESE JOURNAL OF VETERINARY RESEARCH Volume: 67 Issue: 4 Pages: 263-273 DOI: 10.14943/jjvr.67.4.26 Published: NOV 2019
• Ryo Imai, Makoto Nagai, Mami Oba, Shoichi Sakaguchi, Makoto Ujike, Ruka Kimura, Moeko Kida, Tsuneyuki Masuda, Moegi Kuroda, Yukie Katayama, Yuki Naoi, Shinobu Tsuchiaka, Tsutomu Omatsu, Hiroshi Yamazato, Shinji Makino and Tetsuya Mizutani.　A novel defective recombinant porcine enterovirus G virus carrying a porcine torovirus papain-like cysteine protease gene and a putative antiapoptosis gene in place of viral structural protein genes. Infect Genet Evol.Volume 75, November 2019, 103975.　 doi:10.1016/j.meegid.2019.103975.　Epub　22 July 2019.
• Miyamoto J, Igarashi M, Watanabe K, Karaki SI, Mukouyama H, Kishino S, Li X, Ichimura A, Irie J, Sugimoto Y, Mizutani T, Sugawara T, Miki T, Ogawa J, Drucker DJ, Arita M, Itoh H, Kimura I.　 Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids.　Nat Commun. 2019 Sep 5;10(1):4007　 doi: 10.1038/s41467-019-11978-0
• Elbadawy, M., Usui, T., Mori, T., Tsunedomi, R., Hazama, S., Nabeta, R., Uchide, T., Fukushima, R., Yoshida, T., Shibutani, M., Tanaka, T., Masuda, S., Okada, R., Ichikawa, R., Omatsu, T., Mizutani, T., Katayama, Y., Noguchi, S., Iwai, S., Nakagawa, T., Shinohara, Y., Kaneda, M., Yamawaki, H., Sasaki, K. Establishment of a novel experimental model for muscle-invasive bladder cancer using a dog bladder cancer organoid culture.  Cancer Science (Cancer Sci.). 110(9):2806-2821, 2019.
• Oba M, Naoi Y, Ito M, Masuda T, Katayama Y, Sakaguchi S, Omatsu T, Furuya T, Yamasato H, Sunaga F, Makino S, Mizutani T, Nagai M. Metagenomic identification and sequence analysis of a Teschovirus A-related virus in porcine feces in Japan, 2014-2016. Infect Genet Evol. 2018 Dec;66:210-216.
• Takemae H, Basri C, Mayasari NLPI, Tarigan R, Shimoda H, Omatsu T, Supratikno, Pramono D, Cahyadi DD, Kobayashi R, Iida K, Mizutani T, Maeda K, Agungpriyono S, Hondo E. Isolation of Pteropine orthoreovirus from Pteropus vampyrus in Garut, Indonesia.　Virus Genes. 54:6: 823-827　2018 Sep 19. doi: 10.1007/s11262-018-1603-y.
• Dao TD, Bui VN, Omatsu T, Katayama Y, Mizutani T, Ogawa H, Imai K.　Application of the SureSelect target enrichment system for next-generation sequencing to obtain the complete genome sequence of bovine leukemia virus.　Arch Virol. 2018 Nov;163(11):3155-3159.
• Masuda T, Sunaga F, Naoi Y, Ito M, Takagi H, Katayama Y, Omatsu T, Oba M, Sakaguchi S, Furuya T, Yamasato H, Shirai J, Makino S, Mizutani T, Nagai M.　Whole genome analysis of a novel picornavirus related to the Enterovirus/Sapelovirus supergroup from porcine feces in Japan.　Virus Res. 2018 Sep 15;257:68-73. doi: 10.1016/j.virusres.2018.09.003.
• Omatsu T., Omura M., Katayama Y.,Kimura T., Okumura M., Okumura A., Murata Y., Mizutania T.　Molecular diversity of the faecal microbiota of Toy Poodles in Japan, JOURNAL OF VETERINARY MEDICAL SCIENCE, 80(5):749-754, doi 10.1292/jvms.17-0582
• Rahpaya, SS., Tsuchiaka, S., Kishimoto, M., Oba, M., Katayama, Y., Nunomura, Y., Kokawa, S., Kimura, T., Kobayashi, A., Kirino, Y., Okabayashi, T., Nonaka, N., Mekata, H., Aoki, H., Shiokawa, M., Umetsu, M., Morita, T., Hasebe, A., Otsu, K., Asai, T., Yamaguchi, T., Makino, S., Murata, Y., Abi, AJ., Omatsu, T., Mizutani, T. Dembo polymerase chain reaction technique for detection of bovine abortion, diarrhea, and respiratory disease complex infectious agents in potential vectors and reservoirs. Journal of Veterinary Science (J. Vet. Sci.). 19.3: 350, doi 10.4142/jvs.2018.19.3.350
• Mekata, H., Yamamoto, M., Hamabe, S., Tanaka, H., Omatsu, T., Mizutani, T., Hause, BM., Okabayashi, T. Molecular epidemiological survey and phylogenetic analysis of bovine influenza D virus in Japan. Transboundary and emerging diseases (Transbound. Emerg. Dis.). 65:2, e355-e360, 10.1111/tbed.12765
• Oba, M., Katayama, Y., Tsuchiaka, S., Omatsu, T., Murata, Y., Ohya, K., Makino, S., Nagai, M., Mizutani T. Discovery of genome of an immunodeficiency-associated virus-like virus from pig feces in Japan. Journal of Veterinary Research. (J. Vet. Res.). 66.1: 53-56, doi 10.14943/jjvr.66.1.53
• Okada, A., Suganuma, S., Badr, Y., Omatsu, T., Mizutani, T., Ohya, K., Fukushi, H. Decreased expression of the immediate early protein, ICP4, by deletion of the tegument protein VP22 of equine herpesvirus type 1. Journal of Veterinary Medical Science (J. Vet. Med. Sci.).80:2, 311-315, 10.1292/jvms.17-0380
• Tsuchiaka, S., Naoi, Y., Imai, R., Masuda, T., Ito, M., Akagami, M., Ouchi, Y., Ishii, K, Sakaguchi, S., Omatsu, T., Katayama, Y., Oba, M., Shirai, J., Satani, Y., Takashima, Y., Taniguchi, Y., Takasu, M., Madarame, H., Sunaga, F., Aoki, H., Makino, S., Mizutani, T., Nagai, M. Genetic diversity and recombination of enterovirus G strains in Japanese pigs: High prevalence of strains carrying a papain-like cysteine protease sequence in the enterovirus G population. PLoS One (PLoS One). 13: e0190819, 2018
• Oba, M., Tsuchiaka, S., Omatsu, T., Katayama, Y., Otomaru, K., Hirata, T., Aoki, H., Murata, Y., Makino, S., Nagai, M., Mizutani, T. A new comprehensive method for detection of livestock-related pathogenic viruses using a target enrichment system.　 Biochemical and Biophysical Research Communications (Biochem. Biophys. Res. Commun.). 495:2 1871-1877 10.1016/j.bbrc.2017.12.017
• Kobayashi, D., Isawa. H., Fujita, R., Murota, K., Itokawa, K., Higa, Y., Katayama, Y., Sasaki, T., Mizutani, T., Iwanaga, S., Ohta, N., Garcia-Bertuso, A., Sawabe, K. Isolation and characterization of a new iflavirus from Armigeres spp. mosquitoes in the Philippines. Journal of General Virology (J. Gen. Virol.). 98: 2876-2881, 2017
• Oba, M., Katayama, Y., Naoi, Y., Tsuchiaka, S., Omatsu, T., Okumura, A., Nagai, M., Mizutani, T.　 Discovery of fur seal feces-associated circular DNA virus in swine feces in Japan.　Journal of Veterinary Medical Science (J. Vet. Med. Sci.). 79(10):1664-1666, 2017
• Gronsang, D., Bui, AN., Trinh, DQ., Bui, VN., Nguyen, KV., Can, MX., Omatsu, T., Mizutani, T., Nagai, M., Katayama, Y., Thampaisarn, R., Ogawa, H., Imai, K. Characterization of cross-clade monoclonal antibodies against H5N1 highly pathogenic avian influenza virus and their application to the antigenic analysis of diverse H5 subtype viruses. Archives of Virology (Arch. Virol.). 162(8):2257-2269, 2017
• Taniguchi, S., Maeda, K., Horimoto, T., Masangkay ,JS., Puentespina, R., Alvarez, J., Eres, E., Cosico, E., Nagata, N., Egawa, K., Singh, H., Fukuma, A., Yoshikawa, T., Tani, H., Fukushi, S., Tsuchiaka, S., Omatsu, T., Mizutani, T., Une, Y., Yoshikawa, Y., Shimojima, M., Saijo, M., Kyuwa, S. First isolation and characterization of pteropine orthoreoviruses in fruit bats in the Philippines. Archives of Virology (Arch. Virol.). 162(6):1529-1539, 2017