大松　勉

Professional Career

経歴

2007/04/01 - 2010/03/31:国立感染症研究所　ウイルス第一部　第二室　研究員
2010/04/01 - 現在 : 国立感染症研究所　ウイルス第一部　第二室　協力研究員
2010/05/01 - 2012/08/31 : 大塚製薬株式会社　新薬開発本部　開発部
2012/09/01 - 現在 : 東京農工大学　農学部附属国際家畜感染症防疫研究教育センター　家畜感染症経済分析学研究部門　講師
2015/04/01 - 現在 : 岐阜大学大学院　連合獣医学研究科　講師

Academic Degrees

学位

2007/3 : 博士（獣医学）東京大学

Research Interests

キーワード

農業経済学、応用獣医学、ウイルス学

Publications

論文

• Elbadawy M, Fujisaka K, Yamamoto H, Tsunedomi R, Nagano H, Ayame H, Ishihara Y, Mori T, Azakami D, Uchide T, Fukushima R, Abugomaa A, Kaneda M, Hideyuki M Yamawaki, Shinohara Y, Omatsu T, Mizutani T, Usui T, Sasaki K. Establishment of an experimental model of normal dog bladder organoid using a three-dimensional culture method. Biomedicine & Pharmacotherapy. 151:113105. 2022.

• Elbadawy M, Kato Y, Saito N, Hayashi K, Abugomaa A, Kobayashi M, Yoshida T, Shibutani M, Kaneda M, Yamawaki H, Mizutani T, Lim CK, Saijo M, Sasaki K, Usui T, Omatsu T. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-Associated Viruses, SARS-CoV-2 and Pteropine Orthoreovirus. Int J Mol Sci. 2021 Oct 5;22(19):10763

• Elbadawy M, Kato Y, Saito N, Hayashi K, Abugomaa A, Kobayashi M, Yoshida T, Shibutani M, Kaneda M, Yamawaki H, Mizutani T, Lim C-K, Saijo M, Sasaki K, Usui T, Omatsu T. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-associated Viruses, SARS-CoV-2 and Pteropine orthoreovirus. International Journal of Molecular Sciences, 22 (19) 10763, 2021
• Iida A, Takemae H, Tarigan R, Kobayashi R, Kato H, Shimoda H, Omatsu T, Supratikno, Basri C, Mayasari NLPI, Agungpriyono S, Maeda K, Mizutani T, Hondo E. Viral-derived DNA invasion and individual variation in an Indonesian population of large flying fox Pteropus vampyrus. J Vet Med Sci. 2021 Jul 2;83(7):1068-1074.
• Yossapol M, Yamamoto M, Sugiyama M, Odoi JO, Omatsu T, Mizutani T, Ohya K, Asai T. Association between the bla(CTX-M-14)-harboring Escherichia coli Isolated from Weasels and Domestic Animals Reared on a University Campus. Antibiotics (Basel). 2021 Apr 13;10(4):432.
• Supriyono, Kuwata R, Torii S, Shimoda H, Ishijima K, Yonemitsu K, Minami S, Kuroda Y, Tatemoto K, Tran NTB, Takano A, Omatsu T, Mizutani T, Itokawa K, Isawa H, Sawabe K, Takasaki T, Yuliani DM, Abiyoga D, Hadi UK, Setiyono A, Hondo E, Agungpriyono S, Maeda K. Mosquito-borne viruses, insect-specific flaviviruses (family Flaviviridae, genus Flavivirus), Banna virus (family Reoviridae, genus Seadornavirus), Bogor virus (unassigned member of family Permutotetraviridae), and alphamesoniviruses 2 and 3 (family Mesoniviridae, genus Alphamesonivirus) isolated from Indonesian mosquitoes. J Vet Med Sci. 2020 Jul 31;82(7):1030-1041. doi: 10.1292/jvms.20-0261. Epub 2020 May 25
• Tran GTH, Sultan S, Osman N, Hassan MI, VAN Dong H, Dao TD, Omatsu T, Katayama Y, Mizutani T, Takeda Y, Ogawa H, Imai K. Molecular characterization of full genome sequences of Newcastle disease viruses circulating among vaccinated chickens in Egypt during 2011-2013. J Vet Med Sci. 2020 Jun 24;82(6):809-816. doi: 10.1292/jvms.19-0623. Epub 2020 Apr 20
• Adenyo C, Ohya K, Qiu Y, Takashima Y, Ogawa H, Matsumoto T, Thu MJ, Sato K, Kawabata H, Katayama Y, Omatsu T, Mizutani T, Fukushi H, Katakura K, Nonaka N, Inoue-Murayama M, Boniface K, Nakao R.　 Bacterial and protozoan pathogens/symbionts in ticks infecting wild grasscutters Thryonomys swinderianus in Ghana.　Acta Trop. 2020 Feb 5:105388 doi: 10.1016/j.actatropica.2020.105388
• Sunaga F, Tsuchiaka S, Kishimoto M, Aoki H, Kakinoki M, Kure K, Okumura H, Okumura M, Okumura A, Nagai M, Omatsu T, Mizutani T.　 Development of a one-run real-time PCR detection system for pathogens associated with porcine respiratory diseases.　J Vet Med Sci. 82:2:217-223, doi: 10.1292/jvms.19-0063,2020
• Elbadawy, M., Yamanaka, M., Goto, Y., Hayashi, K., Tsunedomi, R., Hazama, S., Nagano, H., Yoshida, T., Shibutani, M., Ichikawa, R., Nakahara, J., Omatsu, T., Mizutani, T., Katayama, Y., Shinohara, Y., Abugomaa, A., Kaneda, M., Yamawaki, H., Usui, T., Sasaki, K.: Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model. Biomaterials 237:119823, 2020
• Kiyonori Kawasaki, Kenji Ohya, Tsutomu Omatsu, Yukie Katayama, Yasuhiro Takashima, Tsuyoshi Kinoshita, Justice Opare Odoi, Kotaro Sawai, Hideto Fukushi, Hirohito Ogawa, Miho Inoue-Murayama, Tetsuya Mizutani, Christopher Adenyo, Yoshiki Matsumoto, Boniface Kayang, Comparative Analysis of Fecal Microbiota in Grasscutter (Thryonomys swinderianus) and Other Herbivorous Livestock in Ghana Microorganisms 2020, 8(2), 265, https://doi.org/10.3390/microorganisms8020265
• Doysabas KCC, Oba M, Furuta M, Iida K, Omatsu T, Furuya T, Okada T, Sutummaporn K, Shimoda H, Wong ML, Wu CH, Ohmori Y, Kobayashi R, Hengjan Y, Yonemitsu K, Kuwata R, Kim YK, Han SH, Sohn JH, Han SH, Suzuki K, Kimura J, Maeda K, Oh HS, Endoh D, Mizutani T, Hondo E. Encephalomyocarditis virus is potentially derived from eastern bent-wing bats living in East Asian countries. Virus Res. 2019 Jan 2,259:62-67
• Huong, GTT ; Van, HD ; Duy, TD ; Iskender, S; Mairambek, I ; Omatsu, T; Katayama, Y; Mizutani, T ; Ozeki, Y ; Takeda, Y; Ogawa, H ; Imai, K Molecular characterization of a virulent strain of Newcastle disease virus isolated from a diseased chicken in Kyrgyzstan in 2016 JAPANESE JOURNAL OF VETERINARY RESEARCH Volume: 67 Issue: 4 Pages: 263-273 DOI: 10.14943/jjvr.67.4.26 Published: NOV 2019
• Ryo Imai, Makoto Nagai, Mami Oba, Shoichi Sakaguchi, Makoto Ujike, Ruka Kimura, Moeko Kida, Tsuneyuki Masuda, Moegi Kuroda, Yukie Katayama, Yuki Naoi, Shinobu Tsuchiaka, Tsutomu Omatsu, Hiroshi Yamazato, Shinji Makino and Tetsuya Mizutani.　A novel defective recombinant porcine enterovirus G virus carrying a porcine torovirus papain-like cysteine protease gene and a putative antiapoptosis gene in place of viral structural protein genes. Infect Genet Evol.Volume 75, November 2019, 103975.　 doi:10.1016/j.meegid.2019.103975.　Epub　22 July 2019.
• Elbadawy, M., Usui, T., Mori, T., Tsunedomi, R., Hazama, S., Nabeta, R., Uchide, T., Fukushima, R., Yoshida, T., Shibutani, M., Tanaka, T., Masuda, S., Okada, R., Ichikawa, R., Omatsu, T., Mizutani, T., Katayama, Y., Noguchi, S., Iwai, S., Nakagawa, T., Shinohara, Y., Kaneda, M., Yamawaki, H., Sasaki, K. Establishment of a novel experimental model for muscle-invasive bladder cancer using a dog bladder cancer organoid culture.  Cancer Science (Cancer Sci.). 110(9):2806-2821, 2019.
• Oba M, Naoi Y, Ito M, Masuda T, Katayama Y, Sakaguchi S, Omatsu T, Furuya T, Yamasato H, Sunaga F, Makino S, Mizutani T, Nagai M. Metagenomic identification and sequence analysis of a Teschovirus A-related virus in porcine feces in Japan, 2014-2016. Infect Genet Evol. 2018 Dec;66:210-216.
• Takemae H, Basri C, Mayasari NLPI, Tarigan R, Shimoda H, Omatsu T, Supratikno, Pramono D, Cahyadi DD, Kobayashi R, Iida K, Mizutani T, Maeda K, Agungpriyono S, Hondo E. Isolation of Pteropine orthoreovirus from Pteropus vampyrus in Garut, Indonesia.　Virus Genes. 54:6: 823-827　2018 Sep 19. doi: 10.1007/s11262-018-1603-y.
• Dao TD, Bui VN, Omatsu T, Katayama Y, Mizutani T, Ogawa H, Imai K.　Application of the SureSelect target enrichment system for next-generation sequencing to obtain the complete genome sequence of bovine leukemia virus.　Arch Virol. 2018 Nov;163(11):3155-3159.
• Masuda T, Sunaga F, Naoi Y, Ito M, Takagi H, Katayama Y, Omatsu T, Oba M, Sakaguchi S, Furuya T, Yamasato H, Shirai J, Makino S, Mizutani T, Nagai M.　Whole genome analysis of a novel picornavirus related to the Enterovirus/Sapelovirus supergroup from porcine feces in Japan.　Virus Res. 2018 Sep 15;257:68-73. doi: 10.1016/j.virusres.2018.09.003.
• Omatsu T., Omura M., Katayama Y.,Kimura T., Okumura M., Okumura A., Murata Y., Mizutania T.　Molecular diversity of the faecal microbiota of Toy Poodles in Japan, JOURNAL OF VETERINARY MEDICAL SCIENCE, 80(5):749-754, doi 10.1292/jvms.17-0582
• Rahpaya, SS., Tsuchiaka, S., Kishimoto, M., Oba, M., Katayama, Y., Nunomura, Y., Kokawa, S., Kimura, T., Kobayashi, A., Kirino, Y., Okabayashi, T., Nonaka, N., Mekata, H., Aoki, H., Shiokawa, M., Umetsu, M., Morita, T., Hasebe, A., Otsu, K., Asai, T., Yamaguchi, T., Makino, S., Murata, Y., Abi, AJ., Omatsu, T., Mizutani, T. Dembo polymerase chain reaction technique for detection of bovine abortion, diarrhea, and respiratory disease complex infectious agents in potential vectors and reservoirs. Journal of Veterinary Science (J. Vet. Sci.). 19.3: 350, doi 10.4142/jvs.2018.19.3.350
• Mekata, H., Yamamoto, M., Hamabe, S., Tanaka, H., Omatsu, T., Mizutani, T., Hause, BM., Okabayashi, T. Molecular epidemiological survey and phylogenetic analysis of bovine influenza D virus in Japan. Transboundary and emerging diseases (Transbound. Emerg. Dis.). 65:2, e355-e360, 10.1111/tbed.12765
• Oba, M., Katayama, Y., Tsuchiaka, S., Omatsu, T., Murata, Y., Ohya, K., Makino, S., Nagai, M., Mizutani T. Discovery of genome of an immunodeficiency-associated virus-like virus from pig feces in Japan. Journal of Veterinary Research. (J. Vet. Res.). 66.1: 53-56, doi 10.14943/jjvr.66.1.53
• Okada, A., Suganuma, S., Badr, Y., Omatsu, T., Mizutani, T., Ohya, K., Fukushi, H. Decreased expression of the immediate early protein, ICP4, by deletion of the tegument protein VP22 of equine herpesvirus type 1. Journal of Veterinary Medical Science (J. Vet. Med. Sci.).80:2, 311-315, 10.1292/jvms.17-0380
• Tsuchiaka, S., Naoi, Y., Imai, R., Masuda, T., Ito, M., Akagami, M., Ouchi, Y., Ishii, K, Sakaguchi, S., Omatsu, T., Katayama, Y., Oba, M., Shirai, J., Satani, Y., Takashima, Y., Taniguchi, Y., Takasu, M., Madarame, H., Sunaga, F., Aoki, H., Makino, S., Mizutani, T., Nagai, M. Genetic diversity and recombination of enterovirus G strains in Japanese pigs: High prevalence of strains carrying a papain-like cysteine protease sequence in the enterovirus G population. PLoS One (PLoS One). 13: e0190819, 2018
• Oba, M., Tsuchiaka, S., Omatsu, T., Katayama, Y., Otomaru, K., Hirata, T., Aoki, H., Murata, Y., Makino, S., Nagai, M., Mizutani, T. A new comprehensive method for detection of livestock-related pathogenic viruses using a target enrichment system.　 Biochemical and Biophysical Research Communications (Biochem. Biophys. Res. Commun.). 495:2 1871-1877 10.1016/j.bbrc.2017.12.017
• Oba, M., Katayama, Y., Naoi, Y., Tsuchiaka, S., Omatsu, T., Okumura, A., Nagai, M., Mizutani, T.　 Discovery of fur seal feces-associated circular DNA virus in swine feces in Japan.　Journal of Veterinary Medical Science (J. Vet. Med. Sci.). 79(10):1664-1666, 2017
• Gronsang, D., Bui, AN., Trinh, DQ., Bui, VN., Nguyen, KV., Can, MX., Omatsu, T., Mizutani, T., Nagai, M., Katayama, Y., Thampaisarn, R., Ogawa, H., Imai, K. Characterization of cross-clade monoclonal antibodies against H5N1 highly pathogenic avian influenza virus and their application to the antigenic analysis of diverse H5 subtype viruses. Archives of Virology (Arch. Virol.). 162(8):2257-2269, 2017
• Taniguchi, S., Maeda, K., Horimoto, T., Masangkay ,JS., Puentespina, R., Alvarez, J., Eres, E., Cosico, E., Nagata, N., Egawa, K., Singh, H., Fukuma, A., Yoshikawa, T., Tani, H., Fukushi, S., Tsuchiaka, S., Omatsu, T., Mizutani, T., Une, Y., Yoshikawa, Y., Shimojima, M., Saijo, M., Kyuwa, S. First isolation and characterization of pteropine orthoreoviruses in fruit bats in the Philippines. Archives of Virology (Arch. Virol.). 162(6):1529-1539, 2017