渋谷　淳

Professional Career

経歴

2012/10/01-現在 : 東京農工大学　農学部共同獣医学科　獣医病理学研究室　教授
2012/10/01-現在 : 東京農工大学大学院　農学研究院　動物生命科学部門　病態獣医学研究分野　教授

Academic Degrees

学位

1989年　博士（博士）東京医科歯科大学

Research Interests

キーワード

化学物質の毒性，化学発がん，発達期神経毒性，実験病理学

Publications

論文

• Tang, Q., Takashima, K., Zeng, W., Okano, H., Zou, X., Takahashi, Y., Ojiro, R., Ozawa, S., Koyanagi, M., Maronpot, R.R., Yoshida, T., Shibutani, M.: Amelioration of lipopolysaccharides-induced impairment of fear memory acquisition by alpha-glycosyl isoquercitrin through suppression of neuroinflammation in rats. Journal of Toxicological Sciences (J. Toxicol. Sci.), 48 (3), 121-137, 2023

• Takashima, K., Okano, H., Ojiro, R., Tang, Q., Takahashi, Y., Ozawa, S., Zou, X., Koyanagi, M., Maronpot, R.R., Yoshida, T., Shibutani, M.: Continuous exposure to alpha-glycosyl isoquercitrin from mid-gestation ameliorates polyinosinic-polycytidylic acid-disrupted hippocampal neurogenesis in rats. Journal of Chemical Neuroanatomy (J. Chem. Neuroanat.) 128, 102219, 2023. DOI: 10.1016/j.jchemneu.2022.102219.

• Ojiro, R., Okano, H., Takahashi, Y., Takashima, K., Tang, Q., Ozawa, S., Zou, X., Woo, G.H., Shibutani, M.: Comparison of the effect of glyphosate and glyphosate-based herbicide on hippocampal neurogenesis after developmental exposure in rats. Toxicology (Toxicology). 483, 153369, 2023. DOI: 10.1016/j.tox.2022.153369.

• Okano, H., Takashima, K., Takahashi, Y., Ojiro, R., Tang, Q., Ozawa, S., Zou, X., Koyanagi, M., Maronpot, R.R., Yoshida, T., Shibutani, M.: Progressive disruption of neurodevelopment by mid-gestation exposure to lipopolysaccharides and the ameliorating effect of continuous alpha-glycosyl isoquercitrin treatment. Environmental Toxicology (Environ. Toxicol.) DOI:10.1002/tox.23661

• Maeda, N., Shimizu, S., Takahashi, Y., Kubota, R., Uomoto, S., Takesue, K., Takashima, K., Okano, H., Ojiro, R., Ozawa, S., Tang, Q., Jin, M., Ikarashi, Y., Yoshida, T., Shibutani, M.: Oral exposure to lead acetate for 28 days reduces the number of neural progenitor cells but increases the number and synaptic plasticity of newborn granule cells in adult hippocampal neurogenesis of young-adult rats. Neurotoxicity Research (Neurotox. Res.). DOI:10.1007/s12640-022-00577-5

• Takashima, K., Okano, H., Ojiro, R., Tang, Q., Takahashi, Y., Ozawa, S., Zou, X., Koyanagi, M., Maronpot, R.R., Yoshida, T., Shibutani, M.: Continuous exposure to alpha-glycosyl isoquercitrin from gestation ameliorates disrupted hippocampal neurogenesis in rats induced by gestational injection of valproic acid. Neurotoxicity Research (Neurotox. Res.). DOI:10.1007/s12640-022-00574-8

• Yoshida, T., Kobayashi, M., Uomoto, S., Ohshima, K., Hara, E., Katoh, Y., Takahashi, N., Harada, T., Usui, T., Elbadawy, M., Shibutani, M.: The potential of organoids in toxicologic pathology: role of toxicologic pathologists in in vitro chemical hepatotoxicity assessment. Journal of Toxicologic Pathology (J. Toxicol. Pathol.) 35(3): 225–235, 2022.

• Takahashi, Y., Okano, H., Takashima, K., Ojiro, R., Tang, Q., Ozawa, S., Ogawa, B., Woo, G.H., Yoshida, T., Shibutani, M.: Oral exposure to high-dose ethanol for 28 days in rats reduces neural stem cells and immediate nascent neural progenitor cells as well as FOS-expressing newborn granule cells in adult hippocampal neurogenesis. Toxicol. Lett. 360, 20–32, 2022.

• Okano, H., Takashima, K., Takahashi, Y., Ojiro, R., Tang, Q., Ozawa, S., Ogawa, B., Koyanagi, M., Maronpot, R.R., Yoshida, T., Shibutani, M.: Ameliorating effect of continuous alpha-glycosyl isoquercitrin treatment starting from late gestation in a rat autism model induced by postnatal injection of lipopolysaccharides. Chem. Biol. Interact. 351:109767, doi: 10.1016/j.cbi.2021.109767, 2022

• Elbadawy M, Kato Y, Saito N, Hayashi K, Abugomaa A, Kobayashi M, Yoshida T, Shibutani M, Kaneda M, Yamawaki H, Mizutani T, Lim CK, Saijo M, Sasaki K, Usui T, Omatsu T. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-Associated Viruses, SARS-CoV-2 and Pteropine Orthoreovirus. Int J Mol Sci. 2021 Oct 5;22(19):10763

• Shimizu, S., Maeda, N., Takahashi, Y., Uomoto, S., Takesue, K., Ojiro, R., Tang, Q., Ozawa, S., Okano, H., Takashima, K., Woo, G.H., Yoshida, T., Shibutani, M.: Oral exposure to aluminum chloride for 28 days suppresses neural stem cell proliferation and increases mature granule cells in adult hippocampal neurogenesis of young-adult rats. J. Appl.Toxicol., doi: 10.1002/jat.4299, FEB 2022

• Kobayashi, M., Yamashita, R., Ichikawa, R., Shibutani, M., Yoshida, T. (2022). Ectopically Localized Epithelial Cell Clumps in Ulcers Are Derived from Reserved Crypt Stem Cells in a Mouse Model of Ulcerative Colitis. Dig. Dis. Sci., doi: 10.1007/s10620-021-07340-4,

• Ojiro, R., Watanabe, Y., Okano, H., Takahashi, Y., Takashima, K., Tang, Q., Ozawa, S., Saito, F., Akahori, Y., Jin, M., Yoshida, T., Shibutani, M.: Gene expression profiles of multiple brain regions in rats differ between developmental and postpubertal exposure to valproic acid. J. Appl. Toxicol, DOI: 10.1002/jat.4263, 2021

• Elbadawy M, Kato Y, Saito N, Hayashi K, Abugomaa A, Kobayashi M, Yoshida T, Shibutani M, Kaneda M, Yamawaki H, Mizutani T, Lim C-K, Saijo M, Sasaki K, Usui T, Omatsu T. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-associated Viruses, SARS-CoV-2 and Pteropine orthoreovirus. International Journal of Molecular Sciences, 22 (19) 10763, 2021
• Yamashita, R., Yoshida, T., Kobayashi, M., Uomoto, S., Shimizu, S., Takesue, K., Maeda, N., Hara, E., Ohshima, K., Zeng, W., Takahashi, Y., Ikeuchi, A., Okamoto, E., Sugiyama, T., Nagakubo, H., Ichikawa-Seki, M., Shibutani, M.: Leptospiral meningoencephalitis in a raccoon dog. Journal of Veterinary Diagnostic Investigation, 33(6), 1137-1141,2021
• Takahashi, Y., Yamashita, R., Okano, H., Takashima, K., Ogawa, B., Ojiro, R., Tang, Q., Ozawa, S., Woo, G. H., Yoshida, T., Shibutani, M.: Aberrant neurogenesis and late onset suppression of synaptic plasticity as well as sustained neuroinflammation in the hippocampal dentate gyrus after developmental exposure to ethanol in rats. Toxicology, 462 (2021) 152958, 2021. https://doi.org/10.1016/j.tox.2021.152958
• Elbadawy, M., Hayashi, K., Ayame, H., Ishihara, Y., Abugomaa, A., Shibutani, M., Hayashi, S. M., Hazama, S., Takenouchi, H., Nakajima, M., Tsunedomi, R., Suzuki, N., Nagano, H., Shinohara, Y., Kaneda, M., Yamawaki, H., Usui, T., Sasaki, K.: Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids. Biomed. Pharmacother. 142, 112043, 2021. https://doi.org/10.1016/j.biopha.2021.112043
• Takashima, K., Nakajima, K., Shimizu, S., Ojiro, R., Tang, Q., Okano, H., Takahashi, Y., Ozawa,S., Jin, M., Yoshinari, T., Yoshida, T., Sugita-Konishi, Y., Shibutani, M.: Disruption of postnatal neurogenesis and adult-stage suppression of synaptic plasticity in the hippocampal dentate gyrus after developmental exposure to sterigmatocystin in rats. Toxicol. Lett. 349: 69–83, 2021.
• Eguchi, A., Mizukami, S., Nakamura, M., Masuda, S., Murayama, H., Kawashima., M., Inohana, M., Nagahara, R., Kobayashi, M., Yamashita., R., Uomoto, S., Makino, E., Ohtsuka, R., Takahashi, N., Hayashi, S.-M., Maronpot, R.R., Shibutani, M., Yoshida, T.: Metronidazole enhances steatosis-related early-stage hepatocarcinogenesis in high fat diet-fed rats through DNA double-strand breaks and modulation of autophagy. Environ. Sci. Pollut. Res. Int.  https://doi.org/10.1007/s11356-021-15689-2
• Shimizu, S., Okada, R., Itahashi, M., Imaoka, M., Woo, G-H., Yoshida, T., Shibutani, M.: Ectopic splenic adenocarcinoma in a dog. J. Comp. Pathol. 187: 2–6, 2021.
• Elbadawy, M., Sato, Y., Mori, T., Goto, Y., Hayashi, K., Yamanaka, M., Azakami, D., Uchide, T., Fukushima, R., Yoshida, T., Shibutani, M., Kobayashi, M., Shinohara, Y., Abugomaa, A., Kaneda, M., Yamawaki, H., Usui, T., Sasaki, K.: Anti-tumor effect of trametinib in bladder cancer organoid and the underlying mechanism. Cancer Biol. Ther. 22(5-6), 357–371, 2021. https://doi.org/10.1080/15384047.2021.1919004
• Yamashita, R., Takahashi, Y., Takashima, K., Okano, H., Ojiro, R., Tang, Q., Kikuchi, S., Kobayashi, M., Ogawa, B., Jin, M., Kubota, R., Ikarashi, Y., Yoshida, T., Shibutani, M.: Induction of cellular senescence as a late effect and BDNF-TrkB signaling-mediated ameliorating effect on disruption of hippocampal neurogenesis after developmental exposure to lead acetate in rats. Toxicology 456: 152782, 2021.
• Okano, H., Okamura, T., Takahashi, Y., Takashima, K., Ojiro, R., Tang, Q., Jin, M., Kikuchi, S., Ogawa, B., Yoshida, T., Yoshinari, T., Shibutani, M., A 28-day repeated oral dose toxicity study of enniatin complex in mice. The Journal of Toxicological Sciences, 46, 4, 157-165, 2021
• Ideta-Otsuka, M., Miyai, M., Yamamoto, N., Tsuchimoto, A., Tamura, H., Tanemura, K., Shibutani, M., Igarashi, K: Development of a new in vitro assay system for evaluating the effects of chemicals on DNA methylation. The Journal of Toxicological Sciences, 46(2): 83–90, 2021. DOI: 10.2131/jts.46.83
• Masubuchi, Y., Nakahara, J., Kikuchi, S., Okano, H., Takahashi, Y., Takashima, K., Koyanagi, M., Maronpot, R.R., Yoshida, T., Hayashi, S-M., Shibutani, M., Continuous exposure to a-glycosyl isoquercitrin from developmental stages to adulthood is necessary for facilitating fear extinction learning in rats, Journal of Toxicologic Pathology, 33(4), 247-263, 2020. DOI: 10.1293/tox.2020-0025
• Nakahara, J., Masubuchi, Y., Takashima, K., Takahashi, Y., Ichikawa, R., Nakao, T., Koyanagi, M., Maronpot, R.R., Yoshida, T., Hayashi, S., Shibutani, M., Continuous exposure to amorphous curcumin formula facilitates anti-anxiety-like behavior and fear extinction learning in rats, Nutrition Research, 85 (2021): 99-118, 2021. DOI:10.1016/j.nutres.2020.10.007
• Kikuchi, S., Takahashi, Y., Ojiro, R., Takashima, K., Okano, H., Tang, Q., Woo, G-H., Yoshida, T., Shibutani, M., Identification of gene targets of developmental neurotoxicity focusing on DNA hypermethylation involved in irreversible disruption of hippocampal neurogenesis in rats, Journal of Applied Toxicology, DOI: 10.1002/jat.4089. 2020
• Bradley, A.E., Bolon, B., Butt, M.T., Cramer, S.D., Czasch, S., Garman, R.H., George, C., Gröters, S., Kaufmann, W., Kovi, R.C., Krinke, G., Little, P., Narama, I., Rao, D.B., Sharma, A.K., Shibutani, M., Sills, R., Proliferative and non-proliferative lesions of the rat and mouse central and peripheral nervous systems: New and revised INHAND terms, Toxicologic Pathology, 0192623320951154、DOI: 10.1177/0192623320951154
• Abugomaa, A., Elbadawy, M., Yamanaka, M., Goto, Y., Hayashi, K., Mori, T., Uchide, T., Azakami, D., Fukushima, R., Yoshida, T., Shibutani, M., Yamashita, R., Kobayashi, M., Yamawaki, H., Shinohara, Y., Kaneda, M., Usui, T., Sasaki, K., Establishment of 2.5D organoid culture model using 3D bladder cancer organoid culture. Scientific Reports, 10(1), 9393, 2020.
• Ito, Y., Nakajima, K., Masubuchi, Y., Kikuchi, S., Okano, H., Saito, F., Akahori, Y., Jin, M., Yoshida, T., Shibutani, M., Downregulation of low-density lipoprotein receptor class A domain-containing protein 4 (Ldlrad4) in the liver of rats treated with nongenotoxic hepatocarcinogen to induce transforming growth factor beta signaling promoting cell proliferation and suppressing apoptosis in early hepatocarcinogenesis, Journal of Applied Toxicology, 40 (11), 1467-1479, 2020
• Elbadawy, M., Yamanaka, M., Goto, Y., Hayashi, K., Tsunedomi, R., Hazama, S., Nagano, H., Yoshida, T., Shibutani, M., Ichikawa, R., Nakahara, J., Omatsu, T., Mizutani, T., Katayama, Y., Shinohara, Y., Abugomaa, A., Kaneda, M., Yamawaki, H., Usui, T., Sasaki, K.: Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model. Biomaterials 237:119823, 2020
• Nakajima, K., Ito, Y., Kikuchi S., Okano, H., Takashima, T., Woo, G.-H., Yoshida, T., Yoshinari T., , Sugita-Konishi, Y., Shibutani, M., Developmental Exposure to Diacetoxyscirpenol Reversibly Disrupts Hippocampal Neurogenesis by Inducing Oxidative Cellular Injury and Suppressed Differentiation of Granule Cell Lineages in Mice. Food Chemical Toxicology (Food Chem Toxicol.), 136, 111046, 2020.
• Ito, Y., Nakajima, K., Masubuch, Y., Kikuchi, S., Saito, F., Akahori, Y., Jin, M., Yoshida, T., Shibutani, M.: Differential responses on energy metabolic pathway reprogramming between genotoxic and non-genotoxic hepatocarcinogens in rat liver cells. Journal of Toxicologic Pathology (J. Toxicol. Pathol.)　32 (4), 261-274, 2019
• Tanaka, T., Masubuchi, Y., Okada, R., Nakajima, K., Nakamura, K., Masuda, S., Nakahara, J., Maronpot, R.R., Yoshida, T., Koyanagi, M., Hayashi, S.M., Shibutani, M. Ameliorating effect of postweaning exposure to antioxidant on disruption of hippocampal neurogenesis induced by developmental hypothyroidism in rats. Journal of Toxicological Sciences (J. Toxicol. Sci.). 44(5), 357-372, 2019
• Masubuchi, Y., Tanaka, T., Okada, R., Ito, Y., Nakahara, J., Kikuchi, S., Watanabe ,Y., Yoshida, T., Maronpot,,R.R., Koyanagi, M., Hayashi, S.M., Shibutani, M. Lack of preventive effect of maternal exposure to alpha-glycosyl isoquercitrin and alpha-lipoic acid on developmental hypothyroidism-induced aberrations of hippocampal neurogenesis in rat offspring.  Journal of Toxicologic Pathology(J. Toxicol. Pathol.). 32(3), 165-180, 2019 .
• Watanabe, Y., Nakajima, K., Ito, Y., Akahori, Y., Saito, F., Woo, G.H., Yoshida, T., Shibutani, M., Twenty-eight-day repeated oral doses of sodium valproic acid increases neural stem cells and suppresses differentiation of granule cell lineages in adult hippocampal neurogenesis of postpubertal rats. Toxicology Letter (Toxico.l Lett.). 312, 195-203, 2019
• Ito, N., Yoshida, T., Ichikawa, R., Makino, E., Akema, S., Fukumori, J., Takahashi, N., Nakahara, J., Yamashita, R., Orihara, K., Kobayashi, M., Xiantao, H., Watanabe, Y., Mizukami, S., Shibutani, M. Clinical and pathological characteristics of acute myelogenous leukemia in a female koala with diabetes mellitus, Journal of Veterinary Medical Science (J. Vet. Med. Sci.). 81(8), 1229-1233, 2019.
• Elbadawy, M., Usui, T., Mori, T., Tsunedomi, R., Hazama, S., Nabeta, R., Uchide, T., Fukushima, R., Yoshida, T., Shibutani, M., Tanaka, T., Masuda, S., Okada, R., Ichikawa, R., Omatsu, T., Mizutani, T., Katayama, Y., Noguchi, S., Iwai, S., Nakagawa, T., Shinohara, Y., Kaneda, M., Yamawaki, H., Sasaki, K. Establishment of a novel experimental model for muscle-invasive bladder cancer using a dog bladder cancer organoid culture.  Cancer Science (Cancer Sci.). 110(9):2806-2821, 2019.
• Ito, Y., Nakajima, K., Masubuchi, Y., Kikuchi, S., Saito, F., Akahori, Y., Jin, M., Yoshida, T., Shibutani, M.: Expression Characteristics of Genes Hypermethylated and Downregulated in Rat Liver Specific to Nongenotoxic Hepatocarcinogens. Toxicological Sciences (Toxicol. Sci.) 169(1): 122–136, 2019
• Okada, R., Masubuchi, Y., Tanaka, T., Nakajima, K., Masuda, S., Namamura, K., Maronpot, R.R., Yoshida, T., Koyanagi, M., Hayashi, S-M., Shibutani, M.: Continuous exposure to alpha-glycosyl isoquercitrin from developmental stage facilitates fear extinction learning in rats. Journal of Functional Foods (J. Funct. Foods) 55(2019): 312–324, 2019
• Nakajima, K., Tanaka, T., Masubuchi, Y., Ito, Y., Kikuchi, S., Woo, G-H., Yoshida, T., Shibutani, M.: Developmental exposure of mice to T-2 toxin increases astrocytes and hippocampal neural stem cells expressing metallothionein. Neurotoxicity Research (Neurotox. Res.) 35(3): 668–683, 2019
• Tanaka, T., Nakajima, K., Masubuchi, Y., Ito, Y., Kikuchi, S., Ideta-Ohtsuka, M., Woo, G-H., Yoshida, T., Igarashi, K., Shibutani, M.: Aberrant epigenetic gene regulation in hippocampal neurogenesis of mouse offspring following maternal exposure to 3,3’-iminodipropionitrile. The Journal of Toxicological Sciences (J. Toxicol. Sci.) 44(2): 93–105, 2019.