イベント情報
【GIR公開セミナー】 Dr. Hiroaki Matsunami / デューク大学 School of Medicine（米国）
| 日時 | 2024.8.6（16：00～17：00） |
|---|---|
| 会場 | |
| 講演者 | Dr. Hiroaki Matsunami |
| 所属機関 | デューク大学 School of Medicine （米国） |
| 講演タイトル | "From Molecules to Senses: The Science of Odor Recognition" ＜要旨＞ Our sense of smell helps us identify a wide range of different smells. The mammalian olfactory system uses odorant receptors (ORs) to detect various odors, but we don't fully understand how these receptors work. ORs belong to a family of G protein-coupled receptors (GPCRs) and can recognize many different types of odor molecules. There are two main classes of ORs: Class I ORs, which are sensitive to carboxylic acids, and Class II ORs, which detect a wide variety of odors and make up most of the ORs in mammals. Our research focuses on how these odor molecules bind to and activate ORs. Using cryo-electron microscopy (cryo-EM), we studied the structure of a human Class I OR, OR51E2, bound to propionate, helping us understand how Class I ORs interact with carboxylic acids. Now, we have investigated Class II ORs by designing and creating OR proteins that represent specific subfamilies. We used these engineered proteins to determine the structures of three different Class II ORs bound to their odor molecules. Our studies reveal how Class II ORs recognize odor molecules and show both common and unique features in their binding sites compared to Class I ORs. By analyzing point mutations and using computer simulations, our study provides a better understanding of how ORs recognize odors, paving the way for future research in this area. |
| 言語 | 英語 |
| 対象 | どなたでも、ご参加いただけます。 |
| 共催 | グローバルイノベーション研究院 ライフサイエンス分野 福谷チーム 卓越大学院プログラム |
| お問い合わせ窓口 | グローバルイノベーション研究院・工学研究院 福谷 洋介 e-mail: fukutani(ここに@ を入れてください）cc.tuat.ac.jp |
| 備考 | 本セミナーは、対面型のみの開催となります。 |
このページの上部へ