メニュー
日時 | 2022.12.15(16:00~17:00) |
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会場 | |
講演者 | Dr. Yoshifumi Itoh |
所属機関 | オックスフォード大学 (英国) |
講演タイトル | ◆"MT1-MMP: a major player in tissue homeostasis, tissue destruction, and cellular invasion " <講演要旨> Fibrillar collagen is a major structural protein in mammals, and its tissue levels are tightly regulated by its production and proteolytic degradation. If the production exceeds, tissue fibrosis will occur; if the degradation exceeds, tissue architecture will be destroyed. There are five collagen-degrading enzymes under neutral pH in humans, including MMP-1, MMP-2, MMP-8, MMP-13, and MT1-MMP. Among them, MT1-MMP is the only type I transmembrane proteinase, and it degrades collagen and other substrates on the cell surface. Accumulating evidence suggests that MT1-MMP is a crucial enzyme regulating tissue homeostasis, tissue destruction, and cellular invasion in various pathophysiological conditions. In this seminar, the roles and regulations of MT1-MMP in these processes will be discussed. |
言語 | 英語 |
対象 | どなたでも、ご参加いただけます。 |
共催 | グローバルイノベーション研究院 ライフサイエンス分野 稲田ユニット 卓越大学院プログラム |
お問い合わせ窓口 | グローバルイノベーション研究院・工学研究院 稲田 全規 e-mail: inada (ここに@ を入れてください) cc.tuat.ac.jp |
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